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Tony Zador
@
TonyZador
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Neuroscientist at CSHL. Interested in neuroAI, connectomics, and auditory cortex.
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542
Tweetovi
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380
Pratim
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3.365
Osobe koje vas prate
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| Tony Zador proslijedio/la je tweet | ||
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Andrew Hardaway
@hardawayja
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2. velj |
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Where do people currently stand with the best opsin to use for pathway-specific inhibition?
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Tony Zador
@TonyZador
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1. velj |
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I'm not sure i understand.
The way i think about it, the functional goals (eg vision) determine which circuits (eg ones with orientation columns) evolution selects for. no?
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Tony Zador
@TonyZador
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1. velj |
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True. Although I was thinking that "journal papers" might also be considered to fulfill the same role.
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Tony Zador
@TonyZador
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1. velj |
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also, I don’t think developmental plasticity is necessarily more efficient in general. I think it is complementary, more precise in that it has the potential to be more specific (sensitive to pair wise neural interactions)
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Tony Zador
@TonyZador
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1. velj |
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My guess is it was the other way: Hebbian learning hijacked activity dependent developmental plasticity.
Not sure though
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| Tony Zador proslijedio/la je tweet | ||
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Adam J Calhoun
@neuroecology
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1. velj |
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In dark, tunicates (a small animal with only 177 neurons!) will swim upward. When it's light, they don't distinguish between up and down.
How do they switch between these contextual behaviors?
👇how antennal cells and photoreceptors interact
sciencedirect.com/science/articl… pic.twitter.com/dUjt8XsB1r
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Tony Zador
@TonyZador
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31. sij |
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Exactly.
Although people often distinguish between "activity-dependent" and "activity-independent" developmental rules, from a computational point of view the more relevant issue is whether the rule is "data-dependent" or "data-independent" (of data from the outside world).
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Tony Zador
@TonyZador
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31. sij |
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Some rules can be specified more compactly using activity. Suppose you need a L3 neuron to get input from L4 neurons driven by L or R eye (but not both). Could be done with molecular tags, but easier to do with a Hebbian winner-take-all circuit.
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| Tony Zador proslijedio/la je tweet | ||
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NRDlab
@NRDlab
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29. sij |
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We are looking for postdocs or grad students to act as conference mentors for #cosyne20 (aka #cosyne2020) undergraduate travel grant winners. Free registration for the main meeting and a chance to help students at the start of their journey.
Apply here: tiny.cc/4jmcjz
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Tony Zador
@TonyZador
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28. sij |
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completely agree. It's not either/or.
The overall project can be curiosity based.
And there can be room for creativity within the project. But it is easy to default to a top-down model that may not be satisfying for worker bees.
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Tony Zador
@TonyZador
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28. sij |
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Team big science is great, as long as it's not at the expense of curiosity driven science
A foundation of modern mobio, PCR, can be traced to fortuitous discoveries by people wondering how life exists in boiling water
One example of many
observer.com/2017/05/dna-re…
@AdamHantman
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Tony Zador
@TonyZador
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28. sij |
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Bell labs used to give people a lot of freedom to pursue their ideas.
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Tony Zador
@TonyZador
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28. sij |
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I think a lot of physicists fled physics (for neuroscience and other fields) precisely to get away from the "cog in the wheel" model of research.
Some people like the freedom to pursue their own crazy ideas.
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Tony Zador
@TonyZador
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27. sij |
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I think this explains each army alone but not how the two armies maintain borders and keep the peace. (But I didn’t read beyond abstract)
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Tony Zador
@TonyZador
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27. sij |
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How does this work? twitter.com/neurosocialsel…
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Tony Zador
@TonyZador
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25. sij |
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I am genuinely puzzled by the idea of a virtual talk. Why not just make a youtube video, and perhaps answer questions at the end? Maybe even by email, or in the comments section?
Or maybe transcribe the talk (nicely formatted, along with slides)?
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Justus
@JustusKebschull
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25. sij |
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So, what is this paper about? SYNPLA is a method to label synapses in a specific pathway that recently underwent LTP. The principle is simple. We exploit the fact that after LTP GluA1 temporarily moves into the synapse from extra-synaptic pools.
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Tony Zador
@TonyZador
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24. sij |
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in what way is it interactive? I had the impression from @KordingLab that there wasn't much of a feedback channel...
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Justus
@JustusKebschull
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24. sij |
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New paper out in PNAS today. Long-running collaboration between Malinow and @TonyZador labs brought to fruition by Kim Dore! Check it out.
SYNPLA, a method to identify synapses displaying plasticity after learning pnas.org/content/early/…
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Tony Zador
@TonyZador
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23. sij |
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Then these could be gathered into a compilation, and distribute to scientists in the field (maybe along with a monthly table of contents)?
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