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Thomas Gatliff
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Thomas Gatliff 3. velj
Odgovor korisniku/ci @erik_arnesen
So if potatoes are such a great protein source, then why dont you see the body builder community embrace their widespread consumption?
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David Sinclair, PhD AO 1. velj
Loss of NAD during aging inhibits nuclear-encoded genes for mitochondrial proteins. New work suggests it inhibits DNA repair, releasing pieces of nuclear DNA into the cytoplasm, causing SASP inflammation in aging & cancer
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Thomas Gatliff 1. velj
Just a suggestion, but can I suggest you follow ? He deserves more followers. 😀
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Thomas Gatliff 31. sij
Odgovor korisniku/ci @Stagi566 @theshirarose @drjasonfung
Throwing stones from a glass house are we? How are you more qualified? Looking at your vascularity/water retention it seems you like test eth. Actually your physique shows a newbie so I’m going to guess it’s test sustanon. I know your little secret BTW.. Don’t throw stones. 😉
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Thomas Gatliff 31. sij
Odgovor korisniku/ci @theshirarose @drjasonfung
Please check out . He’s not only an amazingly understanding and caring individual, but his IDM program has helped allot of people in situations like you seem to be in. Just reach out. Your won’t be disappointed.
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Zhixun Dou 31. sij
Senescent cells display cytoplasmic chromatin that activates cGAS-STING and inflammation. But what triggers cytoplasmic chromatin? Mitochondria play a role. From Peter Adams lab and our lab. Led by
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Aging Highlights 22. sij
A high‐fat diet reverses metabolic disorders and premature aging by modulating insulin and IGF1 signaling in SIRT6 knockout mice
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Aging Highlights 30. sij
Calorie restriction-mediated lifespan extension is independent of Nrf2 in mice
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Thomas Gatliff 30. sij
Athletes specifically use ketogenic diets for offseason adaption training. Meaning, it is clearly a stressor. The same holds true for fasting, BTW. However, the key thing to understand is that no one will win performance world records in ketosis. A person needs carbs for that
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Thomas Gatliff 30. sij
CVD is no doubt multi-factorial with inflammation playing a significant part. Whether a low inflammation diet (LCHF) helps is debatable, but from a known/unknown risk management perspective, having lower LDL (by increasing MUFAs) definitely lowers a persons CVD risk profile.
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Thomas Gatliff 30. sij
Odgovor korisniku/ci @Blagosklonny
Wouldn't this depend on what the underlying goal is? It's rare that someone > 6' tall lives > 100 yrs. Also, as many parents of professional basketball athletes already know, they can pretty much dial in a child's height using HGH. Chronic ketosis would no doubt limit growth.
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Thomas Gatliff 30. sij
Odgovor korisniku/ci @Blagosklonny
Ketosis is a physical stressor similar to a fasting. From an evolutionary standpoint, its performance versus longevity tradeoff. APOE4s are a good example. If they eat enough saturated fat in their diet, viral/bacterial infections are minimal. The tradeoff is early death.
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John 30. sij
Odgovor korisniku/ci @johndotuk
The list they came up with. Hopefully it will inspire further research along the same lines.
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Michael Levin 29. sij
Final version of methods paper on workflow for quantifying calcium/bioelectricity tracking in frog embryos, by Patrick McMillen (from our lab) and Richard Novak, a great collaborator and scientist at :
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Thomas Gatliff 29. sij
Odgovor korisniku/ci @Blagosklonny @TechWzrd i 2 ostali
Lets say a person can take a single large dose w/out sides. However, it takes 4 weeks to get full clearance. Is this better/worse than 1/4 the dose weekly? It just seems like everyone assumes Mannick's original data was optimal when transient studies seem to suggest otherwise.
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Thomas Gatliff 29. sij
Odgovor korisniku/ci @TechWzrd @shunyata2000 i 2 ostali
At least in rodents, the higher the blood level, the more beneficial. In fact, transient treatments seem to have similar benefit suggesting its not increased mTorc1 directly that's the issue, but rather what it influences (autophagy, mitophagy, etc).
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David Sinclair, PhD AO 28. sij
Unlike more robust species, we mammals lose our hearing because we fail to regenerate damaged cochlear hair cells. New study shows long-term activation of Sirt1 with resveratrol increases mitochondria & reduces hair cell loss in old BL6 mice. Music to our👂
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Thomas Gatliff 28. sij
Odgovor korisniku/ci @Blagosklonny @maximumcharacte
Since most rodent studies show higher peak blood levels are more beneficial for revitalizing stem cell pools and preventing cellular senescence, couldn't an argument be made that a single monthly dosage (assuming no sides) is more beneficial that smaller weekly dose? Thoughts?
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Thomas Gatliff 28. sij
Odgovor korisniku/ci @POhukainen @EstebanDL
My point is dont always assume something is universally bad. Evolution gave it a purpose. It might not be relevant in today’s world, but for early man, it probably was a huge advantage
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Thomas Gatliff 28. sij
Odgovor korisniku/ci @POhukainen @EstebanDL
I think the LDL particles are a great example of antagonistic pleiotropy. You see APOE4s all the time that swear they never get sick, yet undoubtably have a higher risk of CVD.
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