|
Susanne Tilk
@
SusanneTilk
Stanford, CA
|
|
Biology PhD candidate @Stanford studying somatic evolution in cancer.
|
|
|
52
Tweetovi
|
109
Pratim
|
203
Osobe koje vas prate
|
| Tweetovi |
| Susanne Tilk proslijedio/la je tweet | ||
|
Chuan Li
@lichuan_Bio
|
30. sij |
|
Ever wonder which tumor suppressor alterations impact drug responses in vivo? Check out our recent work on using improved Tuba-seq to quantify genotype-specific treatment responses in lung cancer. biorxiv.org/content/10.110…
|
||
|
|
||
|
Susanne Tilk
@SusanneTilk
|
10. pro |
|
|
||
| Susanne Tilk proslijedio/la je tweet | ||
|
Dmitri Petrov
@PetrovADmitri
|
3. pro |
|
Check out the paper on G3 by the amazing @SusanneTilk & @sharGblum and coauthors. g3journal.org/content/9/12/4… 1/n
|
||
|
|
||
| Susanne Tilk proslijedio/la je tweet | ||
|
Elora López
@EloraHL
|
13. stu |
|
My first study on somatic mutations in corals! We found heterogeneity among different branches of individual corals. This occurs at a similar frequency as has been reported in humans. Intriguingly, for corals the most common form of that heterogeneity is losses of heterozygosity. twitter.com/OfficialSMBE/s…
|
||
|
|
||
|
Susanne Tilk
@SusanneTilk
|
24. lis |
|
Congrats!
|
||
|
|
||
| Susanne Tilk proslijedio/la je tweet | ||
|
Dmitri Petrov
@PetrovADmitri
|
17. ruj |
|
I am extremely excited about this work on the way natural selection succeeds and crucially fails to weed out deleterious mutations in cancer due to the constraints posed by linkage and Hill-Robertson interference. biorxiv.org/content/10.110… 1/n
|
||
|
|
||
|
Susanne Tilk
@SusanneTilk
|
16. ruj |
|
How successful tumors overcome this deleterious load is an exciting, open question. Similar to constraints in germ-line evolution, we think that preventing protein mis-folding is an important first step. We’d love to hear what you think! (10/10)
|
||
|
|
||
|
Susanne Tilk
@SusanneTilk
|
16. ruj |
|
Thus, this allowed us to estimate that in elevated mutational burden tumors (>95% of cancers), deleterious passengers accumulate and confer an individually-weak, but collectively-substantial fitness cost of ~40% that impacts tumor progression. (9/10)
|
||
|
|
||
|
Susanne Tilk
@SusanneTilk
|
16. ruj |
|
Finally, we demonstrate that a simple evolutionary model incorporating HRI can explain these observed patterns of selection and allowed us to estimate the mean fitness effects of passengers (~1%) and drivers (~18%) – much larger than previously estimated. (8/10)
|
||
|
|
||
|
Susanne Tilk
@SusanneTilk
|
16. ruj |
|
Importantly, we see that attenuated selection on CNAs and SNVs is generic to tumor evolution. This pattern persists across broad and specific tumor sub-type categories. (7/10) pic.twitter.com/bKJ8vSbQUV
|
||
|
|
||
|
Susanne Tilk
@SusanneTilk
|
16. ruj |
|
We see the same trend in somatic CNAs. Using a dN/dS-style statistic called dE/dI (fractional overlap of CNAs in [E]xonic versus [I]ntergenic/[I]ntronic regions) – we similarly see that selection on CNAs attenuates as the mutational burden increases. (6/10) pic.twitter.com/LUg6hlRJFk
|
||
|
|
||
|
Susanne Tilk
@SusanneTilk
|
16. ruj |
|
To test this idea, we calculated dN/dS in tumors stratified by their mutational burden and observe that negative and positive selection attenuates as more mutations accumulate in tumors. (5/10) pic.twitter.com/WF1WIJ02mV
|
||
|
|
||
|
Susanne Tilk
@SusanneTilk
|
16. ruj |
|
Since linkage effects get stronger as mutation rates increase, tumors with elevated mutational burdens should be particularly inefficient at removing deleterious passengers due to genetic hitchhiking and Muller’s Ratchet. (4/10) pic.twitter.com/vVW4z6C6q1
|
||
|
|
||
|
Susanne Tilk
@SusanneTilk
|
16. ruj |
|
We hypothesized that since tumors evolve asexually, under the constraints of genome-wide linkage, mutations are unable to be removed by negative selection (or favored by positive selection). (3/10)
|
||
|
|
||
|
Susanne Tilk
@SusanneTilk
|
16. ruj |
|
Here, we try to resolve why signals of negative selection are largely absent in cancer, yet pre-dominant in the human germ-line. (2/10)
|
||
|
|
||
|
Susanne Tilk
@SusanneTilk
|
16. ruj |
|
Really excited to share the first chapter of my PhD on how genome-wide linkage in cancer reduces the efficacy of selection via Hill-Robertson interference (HRI), with mentors @cd_mcfarland, @PetrovADmitri and @cncurtis. bit.ly/2lTDQnT (1/10)
|
||
|
|
||
| Susanne Tilk proslijedio/la je tweet | ||
|
Ellie Armstrong 🦁🐯
@_ellie_cat
|
25. srp |
|
Today at petrov lab meeting we explored a very important question...which spicy Cheeto is spicier? We double blinded and controlled for Cheeto size but we’re still really confused about whos spicier. @ChesterCheetah, can you help us out? pic.twitter.com/gflnUsHAu7
|
||
|
|
||
| Susanne Tilk proslijedio/la je tweet | ||
|
Christina Curtis
@cncurtis
|
8. velj |
|
Excited to share our new paper @NatureComms on clonal replacement and heterogeneity through neoadjuvant therapy in Her2+ breast cancer: rdcu.be/blOEK. Great work from @caswell_jin and Katherine McNamara and the rest of the team!
|
||
|
|
||
| Susanne Tilk proslijedio/la je tweet | ||
|
Alison Feder
@AlisonFeder
|
14. pro 2018. |
|
We have a new paper on bioRxiv today. It’s not a paper I was planning to write during my first semester as a postdoc. biorxiv.org/content/early/… (1/n)
|
||
|
|
||
| Susanne Tilk proslijedio/la je tweet | ||
|
KerryGeilerSamerotte
@KSamerotte
|
16. stu 2018. |
|
The Geiler-Samerotte lab is recruiting graduate students and postdocs! Graduate students apply here by December 1rst: sols.asu.edu/degrees/grad/e… Postdocs apply here: postdocjobs.com/posting/7054334 pic.twitter.com/9dO9UKWNOF
|
||
|
|
||