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Sarah Constantin
You know how hypothalamic function declines with age? This paper seems to isolate an essential mechanism for that, and shows that it can be reversed. (In mice, of course.)
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Sarah Constantin 30. sij
Odgovor korisniku/ci @s_r_constantin
There's a particular noncoding RNA that is found in the hypothalamus and declines sharply with age. Knock it out and you get shorter-lived, faster-aging mice with more senescence and fewer stem cells in the hypothalamus.
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Sarah Constantin 30. sij
Odgovor korisniku/ci @s_r_constantin
How does this non-coding RNA (Hncsr) work? It binds a protein called YB-1, protecting it from degradation, and this protein inhibits the expression of the senescence marker p16. Not enough Hncsr and you impair the animal's ability to block senescence.
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Sarah Constantin 30. sij
Odgovor korisniku/ci @s_r_constantin
A natural product found in black tea, Theaflavin 3-Gallate, was predicted by a virtual screen of molecules to mimic Hncsr's ability to protect YB-1, and indeed, administering it to middle-aged mice prevented hypothalamic stem cell senescence.
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Sarah Constantin 30. sij
Odgovor korisniku/ci @s_r_constantin
The treated mice, after 6 months, also showed reduced age-related cognitive and motor deficits, better insulin sensitivity, and higher bone mass. The study didn't follow them long enough to test the effect on lifespan.
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Sarah Constantin 30. sij
Odgovor korisniku/ci @s_r_constantin
Of course, this doesn't prove that this is the *only* mechanism causing hypothalamic stem cell decline or aging symptoms downstream of it. But it does show that this is *a* causal mechanism.
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zooko 30. sij
Odgovor korisniku/ci @s_r_constantin
You know how people make graphs of the expected lifespan of humans over time? Like we tend to live a couple of years longer this century than we did last century and so on. I'd like to see that for lab mice.
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José Luis Ricón (Artir) 30. sij
Odgovor korisniku/ci @zooko @s_r_constantin
Ask and thou shalt receive (Thread I did )
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