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Richard B Fuisz
@
richardfuisz
San Francisco, CA
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asking biology (politely) to do useful things.
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Pratim
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Osobe koje vas prate
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Marshall lab
@OMarshall_lab
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10. pro |
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Ok ... so we've now tried this and sequenced verified the results. It works perfectly (and at the same rate as with the NEB HiFi Assembly kit in our hands).
If you're cloning with Gibson, stop adding the snake oil and try it for yourselves :) twitter.com/OMarshall_lab/…
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Richard B Fuisz
@richardfuisz
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16. stu |
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How relevant is this to bio? From a quick pass it looks like the case has ended up revolving around itar - unless you’re emailing smallpox specs, I’m not sure I see how this applies.
agportal-s3bucket.s3.amazonaws.com/uploadedfiles/…
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Richard B Fuisz
@richardfuisz
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9. stu |
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After you account for single cell amplification biases, snp chip errors, and the fact that genetic variance within a family < genetic variance in the UK bio bank, a really impressive polygenic score can translate into a pretty marginal improvement unless you’re very careful.
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Richard B Fuisz
@richardfuisz
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9. stu |
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Disappointed that they left out the importance of # of viable embryos to select from. That substantially reduces power of polygenic scores for prediction.
If in vitro gametogenesis ever gets solved, that’s when these tests become really useful.
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Richard B Fuisz
@richardfuisz
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21. lis |
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Have you read ted Sorensen’s memo to Carl Albert on how to be prepared to assume the presidency? dropbox.com/s/alwuk9t29bwu…
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Richard B Fuisz
@richardfuisz
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11. lis |
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Idk. To be honest, I was just sold by the idea of train tickets at half the price and actually profitable. Maybe it was not to be
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Richard B Fuisz
@richardfuisz
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11. lis |
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My guess is selling to Amtrak sucks, and the economics are probably quite different for freight, but I’m wondering how hard it would be to make a deal for track access say between LA and SF and run an automated train.
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Richard B Fuisz
@richardfuisz
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11. lis |
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Interesting. It doesn’t seem like PTC actually reduces the need for staffing, just the rate of certain types of rare accidents. My hunch is that lots of the staffing costs aren’t the conductors, too.
Are all of those railroad employees actually unionized?
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Richard B Fuisz
@richardfuisz
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11. lis |
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Taxi and tractor trailer drivers have unions, too, though. Are all railroad workers unionized? Could they really prevent a third party from retrofitting say an automated freight train and making a deal to access shared track?
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Richard B Fuisz
@richardfuisz
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11. lis |
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Richard B Fuisz
@richardfuisz
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11. lis |
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Why no hype for autonomous trains? 60% of cost of trains is wages, and they literally ride on rails. pic.twitter.com/eRjJV5JLhN
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Richard B Fuisz
@richardfuisz
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11. lis |
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Richard B Fuisz
@richardfuisz
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7. lis |
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Maybe best odds searching for some tartine starter on a SF bread starter grey market...
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Richard B Fuisz
@richardfuisz
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7. lis |
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The microbe population that survives baking temperatures/storage etc, if they survive at all, would probably be a pretty skewed selection. You’d also have to be careful not to let your SF starter get overtaken by local variants, ensure similar climate, etc.
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Richard B Fuisz
@richardfuisz
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7. lis |
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People do exactly this with bottle conditioned beer quite often.
Bread might be a different story - I’m not a hardcore baker, but it’s my understanding that SF’s local microbe ecosystem also contributes to the uniquely good local sourdough. So it’s more than just the yeast.
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Richard B Fuisz
@richardfuisz
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3. lis |
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Only downside to going to syn bio conferences is that the swag is too bulky. I’ve been walking around all day lugging a tasty looking GMO Papaya... #synbiobeta19
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Richard B Fuisz
@richardfuisz
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30. ruj |
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Also opens up “bostome”, “diegome”, “britome”...
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Richard B Fuisz
@richardfuisz
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30. ruj |
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The Friscosome?
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Richard B Fuisz
@richardfuisz
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29. ruj |
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SF prefers to taxidermy neighborhoods, not animals...
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Richard B Fuisz
@richardfuisz
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29. ruj |
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Woohoo! Let’s stop being so stingy with our planetary neighbors with this whole “life” thing. twitter.com/astroengine/st…
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