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Philip Ball
This very interesting paper (text of a lecture) by Walter Fontana that I'm reading is giving me a lovely perspective on what I was driving at in this piece (1/3)
Many biological models rely on an agency that molecules lack
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Philip Ball 2. velj
Odgovor korisniku/ci @philipcball
See, here's a conventional view of the Wnt/beta-catenin signaling pathway. Note that axin is one of the proteins involved. (2/3)
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Philip Ball 2. velj
Odgovor korisniku/ci @philipcball
Now here, from Walter's paper, is a representation of most of the protein-protein interactions so far identified that involve axin. In what sense then does the preceding image offer an actual molecular-scale picture? What is "happening" in real time? (3/3 + 1 to come)
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Philip Ball 2. velj
Odgovor korisniku/ci @philipcball
His conclusion, then, seems very sound to me: "Today, the uniquely difficult challenge of biology is [not quanitification but] representation. To reason about something you first have to represent it somehow."
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K. VijayRaghavan 2. velj
Odgovor korisniku/ci @philipcball
Can you give the link to the Fontana (lecture) paper, please?
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Philip Ball 3. velj
Odgovor korisniku/ci @kvijayraghavan
Sorry, I'd like to but I'm not completely sure Walter is ready to make it public yet... I hope he will, it is full of interesting ideas.
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