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@philipcball | |||||
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This very interesting paper (text of a lecture) by Walter Fontana that I'm reading is giving me a lovely perspective on what I was driving at in this piece (1/3)
chemistryworld.com/opinion/the-ch…
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Philip Ball
@philipcball
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2. velj |
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See, here's a conventional view of the Wnt/beta-catenin signaling pathway. Note that axin is one of the proteins involved. (2/3) pic.twitter.com/CDiyKBJOgA
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Philip Ball
@philipcball
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2. velj |
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Now here, from Walter's paper, is a representation of most of the protein-protein interactions so far identified that involve axin. In what sense then does the preceding image offer an actual molecular-scale picture? What is "happening" in real time? (3/3 + 1 to come) pic.twitter.com/IEZatQ8BHB
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Philip Ball
@philipcball
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2. velj |
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His conclusion, then, seems very sound to me: "Today, the uniquely difficult challenge of biology is [not quanitification but] representation. To reason about something you first have to represent it somehow."
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K. VijayRaghavan
@kvijayraghavan
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2. velj |
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Can you give the link to the Fontana (lecture) paper, please?
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Philip Ball
@philipcball
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3. velj |
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Sorry, I'd like to but I'm not completely sure Walter is ready to make it public yet... I hope he will, it is full of interesting ideas.
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