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#BAcTrace, a #tweeprint: At least since Francis Crick’s famous review of 1979, neuroscientists have dreamed of ways to identify all the neurons connected to a cell of interest. In the last decade this has become a reality through the widespread use of rabies virus tracers. 1/11 twitter.com/biorxivpreprin… pic.twitter.com/nVGKPvCexH
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Greg Jefferis
@gsxej
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Rabies has been engineered to act as a retrograde tracer, revealing all the inputs to a neuron. However limitations include toxicity and uncertainty about which synapses it crosses. Furthermore, these viruses are not applicable to all species. 2/11
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