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Michael Levin
@
drmichaellevin
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Scientist working at Tufts University; my lab studies patterning and computation in a range of biological systems.
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1.473
Tweetovi
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362
Pratim
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4.371
Osobe koje vas prate
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Michael Levin
@drmichaellevin
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2 h |
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Very excited to be on my way to Penn Institute for Regenerative Medicine symposium on Engineering Cell and Tissue Organization @IRM_UPenn
irm.med.upenn.edu/irm-events-act… pic.twitter.com/uTjSIwBbt0
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Michael Levin
@drmichaellevin
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24 h |
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Found a quite interesting paper on evolution, aging, and mice as a biomedical test model:
sciencedirect.com/science/articl…
from an also interesting (long) podcast episode:
stitcher.com/podcast/kast-m…
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Michael Levin
@drmichaellevin
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24 h |
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A lot of it is the "age" of the head (time from induction) - they get more dominant as they mature.
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Michael Levin
@drmichaellevin
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2. velj |
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Planaria are not an expensive system, comparatively. That part is relatively easy. But, behavior experiments are quite tricky, and state of the art molecular neuroscience techniques aren’t cheap. If you have a solid plan, a typical grant would cover it, I guess.
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Michael Levin
@drmichaellevin
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2. velj |
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no studies yet - wide open area!
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Michael Levin
@drmichaellevin
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1. velj |
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Depends on origin. Cut middle from 2-headed parent - the 2 new heads are basically equivalent. But if induce an ectopic head in presence of mature head, the mature one is dominant and the new one takes time to spread its influence. Mechanism here: biorxiv.org/content/10.110…
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Michael Levin
@drmichaellevin
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26. pro 2016. |
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Permanently 2-headed planaria, being themselves. Footage by Junji Morokuma in the Levin lab, music by Edvard Grieg. pic.twitter.com/cn6zzf1zAv
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Michael Levin
@drmichaellevin
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1. velj |
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Here's one of the long-form essays on Causation in biology expanding on nature.com/articles/s4158…:
"Biophysics of Regenerative Repair Suggests New Perspectives on Biological Causation":
onlinelibrary.wiley.com/doi/full/10.10…
Others' (like @yoginho's) should be out soon in forthcoming collection. pic.twitter.com/e2dKaqWvw9
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Michael Levin
@drmichaellevin
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1. velj |
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sure
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Michael Levin
@drmichaellevin
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1. velj |
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I suspect it's (also) related to plasticity of body to maintain robustness despite developmental change (mutations, parasites, and now, experimental manipulations). Ectopic organs often end up very functional:
jeb.biologists.org/content/216/6/…
The brain can recognize and use ectopic eyes!
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Michael Levin
@drmichaellevin
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31. sij |
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What model systems’ embryos are easily dissociated into cells? Chemical method, ideally (not manual dissection), and we want the cells to stay alive (not for fixation). Can zebrafish? C. elegans? Other invertebrates? The weirder the better. Ideas?
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Michael Levin
@drmichaellevin
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31. sij |
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Rubber Hand Illusion
youtube.com/watch?v=TCQbyg…
& more generally
en.wikipedia.org/wiki/Body_tran…
Isn't it weird that despite long evolutionary time of dependable (constant) body structure, brain is willing to abandon default, & revise somatic self-model after mere ~20 minutes of experience?
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Michael Levin
@drmichaellevin
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30. sij |
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This is quite useful:
"The Node Network is a global directory of developmental and stem cell biologists, designed to help you find speakers, referees, panel members and potential collaborators."
thenode.biologists.com/network/
@the_Node
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Michael Levin
@drmichaellevin
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30. sij |
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Very interesting collection:
"Evolution, Development and Complexity:
Multiscale Evolutionary Models of Complex Adaptive Systems"
springer.com/gp/book/978303…
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Michael Levin
@drmichaellevin
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29. sij |
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Final version of methods paper on workflow for quantifying calcium/bioelectricity tracking in frog embryos, by Patrick McMillen (from our lab) and Richard Novak, a great collaborator and scientist at @wyssinstitute :
authors.elsevier.com/a/1aU2954HFDeiE
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Michael Levin
@drmichaellevin
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28. sij |
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Code & data = long topic, but I can point to interesting example of tissues keeping counterfactual information = representation of goal state to pursue in future. Relevant, as any state of tissue *now* suggests "no separate data". But alternative happens:
authors.elsevier.com/sd/article/S00…
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Michael Levin
@drmichaellevin
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27. sij |
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Classic on multi-headed snakes. pic.twitter.com/XzVR9yKIV4
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Michael Levin
@drmichaellevin
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26. sij |
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Lots to think about here:
ncbi.nlm.nih.gov/pubmed/18406536
"The neuron-level phenomena underlying cognition and consciousness: synaptic activity and the action potential."
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Michael Levin
@drmichaellevin
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26. sij |
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Before very important Jan. event, told myself "no thinking about new directions until all prep is done & we get past it." Oddly, this triggered flood of new ideas (written down for later). Is this a known thing? What strategies do you all use for enhancing actionable creativity? pic.twitter.com/zKkejF932T
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Michael Levin
@drmichaellevin
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26. sij |
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With cells from adult humans, yes. No problem. People throw away biopsies all the time.
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