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Deepta Bhattacharya
Our latest ! A truly equal effort by our group and the Nikolich lab, led by Makiko Watanabe, Rachel Wong, and so many across (@Christineb9528, Ryan Sprissler, many others)
Serological assays for SARS-CoV-2 exposures are challenging due to poor positive predictive values. Ripperger et al. show that combinatorial use of spike receptor binding domain and S2 eliminates...
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Deepta Bhattacharya Oct 13
Replying to @deeptabhattacha
Most of the work was covered in this (mangled) thread. We now have some more data in the 5-7 months post-(mild) infection range. TLDR--spike antibodies still present in all participants. A few nuances to follow...
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Deepta Bhattacharya Oct 13
Replying to @deeptabhattacha
First, neutralizing antibodies were overall very stable. One participant did drop below a PRNT90 titer of 20. I.e. when we diluted the serum 1 part into 20, it failed to block >90% of infection in cells. FWIW, had we plotted a PRNT50, it would still be positive. All others stable
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Deepta Bhattacharya Oct 13
Second, the pandemic hit AZ late, so we don't have a ton of numbers at the 5+ month range. Thankfully, this adds to a collective body of work showing persistent antibodies for at least a few months post-infection. e.g.
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Deepta Bhattacharya Oct 13
Replying to @ForrestKJones
And this one from Richelle Charles:
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Deepta Bhattacharya Oct 13
Replying to @NEJM
And this one from
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Deepta Bhattacharya Oct 13
Replying to @jbloom_lab
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Deepta Bhattacharya Oct 13
Replying to @florian_krammer
Or how about this one from
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Deepta Bhattacharya Oct 13
Replying to @deeptabhattacha
Still not enough evidence? How about this one that goes through 6 months:
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Deepta Bhattacharya Oct 13
Replying to @PepperMarion
This one from shows not only persistent antibody production, but also cellular memory:
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Deepta Bhattacharya Oct 13
Replying to @deeptabhattacha
At least for mild infections, this looks like a pretty conventional antibody response. Yes, antibodies decline initially, but then they settle into a more stable phase just like every other acute viral infection.
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