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Debora Marks
Mission: develop AI for design of biological interventions for environment and human health  (to save the world)
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Debora Marks 25. sij
Odgovor korisniku/ci @KevinKaichuang
Ahh - it may start generating on its own ..
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Debora Marks 24. sij
Odgovor korisniku/ci @ianholmes
And how about biological sequence design?
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Debora Marks 24. sij
Odgovor korisniku/ci @ianholmes
How about the first and best for all protein mutation effects ?
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Debora Marks 24. sij
Odgovor korisniku/ci @AndyBiotech @biorxivpreprint
Even has almost identical accessory genes to 2018 bat ‘SARS’ (not all in new database annotations)
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Debora Marks proslijedio/la je tweet
Andy Biotech 23. sij
Important paper out on via 96% sequence identity to a bat ~80% sequence identity to SARS ~95% AA sequence identity in 7 conserved replicase domains to SARS uses the same cell entry receptor, ACE2, as SARS
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Debora Marks 24. sij
Odgovor korisniku/ci @deboramarks
PS: 99.99% proteins are outside CASP
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Debora Marks 24. sij
: does enalapril work?
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Debora Marks 24. sij
: Anyone notice two ‘accessory’ ORFs not annotated ? Orf13 (aka 9b) (28284:28577) and Orf14 (28734:28955) ~90% to BAT SARS 2017
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Debora Marks 19. sij
That’s why we have to find new ways to infer homology or similarity - and new ways to find structural plasticity
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Debora Marks 18. sij
Predicting structure of designed protein is not harder than natural ones esp when designed have encoded the rules we know - take care with logic there folks ..
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Debora Marks proslijedio/la je tweet
Lior Pachter 18. sij
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Debora Marks 18. sij
Ah .. that’s why I’ve always been such an unhappy person ..
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Debora Marks 18. sij
Thanks all who responded and also thanks to for apologizing.
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Debora Marks 17. sij
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Debora Marks 17. sij
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Debora Marks 17. sij
Odgovor korisniku/ci @noort_zuit
Thx
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Debora Marks 17. sij
Odgovor korisniku/ci @LindorffLarsen @labriataphd i 2 ostali
Not sure it has systematically. We have done some internally and should publish
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Debora Marks 17. sij
Odgovor korisniku/ci @jinboxu_chicago @sandercbio
I’ll check that out - cool if not just indirect training test thing
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Debora Marks proslijedio/la je tweet
Kresten Lindorff-Larsen 17. sij
Thanks. I'm surprised that there is no analysis of the effect of the depth of the alignment and generalisability to proteins with fewer homologues. How much does the method learn something general and how much is based on a more robust extraction of dist distributions from MSAs?
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Debora Marks 17. sij
Odgovor korisniku/ci @jinboxu_chicago @sandercbio
Testable? relies dependencies across evolution - simple. Only other way is real physics.
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