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Chris D McFarland
Cancer Systems Biology Postdoc at Stanford
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Chris D McFarland 5. stu
Odgovor korisniku/ci @PetrovADmitri
Freedom of movement. Harvard/MIT/BU allowed students to join any lab they wanted; Stanford/UCSF/Berkeley didn't. Glad I made the choice I did - I became a Harvard student in an MIT lab (it wasn't planned).
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Rajiv McCoy 19. ruj
Our lab has been awarded an R35 MIRA! Thank you to for supporting our research for the next five years. Now recruiting postdocs and students. Join us in studying the functional and fitness effects of human genomic variation:
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Chris D McFarland 18. ruj
Odgovor korisniku/ci @kaptenkvast @PetrovADmitri i 2 ostali
Exactly, we preserve both flanking nucleotides and the reference base...and we are planning to release the code.
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Chris D McFarland 18. ruj
Odgovor korisniku/ci @kaptenkvast @PetrovADmitri @cncurtis
<,> denotes an inner product, which in our case is simply the cartesian dot product.
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Chris D McFarland 18. ruj
Odgovor korisniku/ci @imartincorena @PetrovADmitri
Also, agreed that it is probably more than protein toxicity. I would think that protein toxicity would be approximately semi-dominant.
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Chris D McFarland 18. ruj
Odgovor korisniku/ci @imartincorena @PetrovADmitri
Lots of people to cite on this one, also:
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Chris D McFarland 18. ruj
Odgovor korisniku/ci @imartincorena @PetrovADmitri
We observe reduction in dN/dS in low VAF (hemizygous or subclonal) mutations too! Agreed that it could be reduced selection, but it also could be due to inefficient selection (e.g. longer residence times of neutral mutations or rapid population expansion following transformation)
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Chris D McFarland 16. ruj
Odgovor korisniku/ci @CalvinMccarter @SusanneTilk i 2 ostali
The originally-postulated reason for recombination was these additive interference effects between mutations under positive and negative selection, but sufficient epistasis can also drive recombination
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Chris D McFarland 16. ruj
Odgovor korisniku/ci @SusanneTilk @PetrovADmitri i 2 ostali
I also want to thank my graduate advisor , who first got me interested in deleterious passengers and their role in cancer.
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Chris D McFarland 4. ožu
Glad to see US universities joining their European colleagues in this fight
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Chris D McFarland 27. sij 2019.
Odgovor korisniku/ci @CancerConnector
I vote precursor. Similar experiment in a different system is good for proving generalizability, but not that you can implement the experiment.
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Chris D McFarland 10. pro 2018.
AI just outperformed traditional protein folding algorithms
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Chris D McFarland 8. stu 2018.
presenting on the effect of the genome-wide mutation rate on patterns of positive and negative selection in cancer
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Chris D McFarland 6. stu 2018.
Vote! California has day-of voter registration.
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Michael Hallett 13. lis 2018.
The first symposium on mathematical and computational oncology (ISMCO), and in a beautiful place. Paper submission is Dec 17.
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Chris D McFarland proslijedio/la je tweet
ᴊᴏʜɴ ᴍᴄᴄᴏʀᴍᴀᴄᴋ 24. kol 2018.
is this: 🐜🦎🐒🙍🏻‍♀️ (today) | | |__| | |___💀 (ancestor) |_____| ↑ | Time Not this: Time → 🐜→🦎→🐒→🙍🏻‍♀️
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Dmitri Petrov 2. tra 2018.
Very proud of this paper by Zoe Rogers, Chris McFarland et al entitled "Mapping the in vivo fitness landscape of lung adenocarcinoma tumor suppression in mice" which just came out in Nature Genetics 1/n
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Dmitri Petrov 3. tra 2018.
Odgovor korisniku/ci @PetrovADmitri
And here is a write up by Stanford News:
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Chris D McFarland 9. lip 2017.
This was the smartest thing NIH has done in years, and it didn't last a month...
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Chris D McFarland 26. svi 2017.
Excited about this recent FDA approval: 1) Its the first pan-cancer drug, 2) It targets cancer's mutator phenotype
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