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Chris D McFarland
@
cd_mcfarland
Palo Alto, CA
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Cancer Systems Biology Postdoc at Stanford
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29
Tweetovi
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166
Pratim
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80
Osobe koje vas prate
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Chris D McFarland
@cd_mcfarland
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5. stu |
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Freedom of movement. Harvard/MIT/BU allowed students to join any lab they wanted; Stanford/UCSF/Berkeley didn't. Glad I made the choice I did - I became a Harvard student in an MIT lab (it wasn't planned).
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Rajiv McCoy
@rajivmccoy
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19. ruj |
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Our lab has been awarded an R35 MIRA! Thank you to @NIGMS @NIH for supporting our research for the next five years. Now recruiting postdocs and students. Join us in studying the functional and fitness effects of human genomic variation: mccoy-lab.org/join
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Chris D McFarland
@cd_mcfarland
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18. ruj |
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Exactly, we preserve both flanking nucleotides and the reference base...and we are planning to release the code.
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Chris D McFarland
@cd_mcfarland
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18. ruj |
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<,> denotes an inner product, which in our case is simply the cartesian dot product.
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Chris D McFarland
@cd_mcfarland
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18. ruj |
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Also, agreed that it is probably more than protein toxicity. I would think that protein toxicity would be approximately semi-dominant.
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Chris D McFarland
@cd_mcfarland
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18. ruj |
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Lots of people to cite on this one, also: biorxiv.org/content/10.110…
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Chris D McFarland
@cd_mcfarland
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18. ruj |
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We observe reduction in dN/dS in low VAF (hemizygous or subclonal) mutations too! Agreed that it could be reduced selection, but it also could be due to inefficient selection (e.g. longer residence times of neutral mutations or rapid population expansion following transformation) pic.twitter.com/qlx4dVszHc
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Chris D McFarland
@cd_mcfarland
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16. ruj |
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The originally-postulated reason for recombination was these additive interference effects between mutations under positive and negative selection, but sufficient epistasis can also drive recombination pnas.org/content/106/16…
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Chris D McFarland
@cd_mcfarland
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16. ruj |
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I also want to thank my graduate advisor @leonidmirny, who first got me interested in deleterious passengers and their role in cancer.
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Chris D McFarland
@cd_mcfarland
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4. ožu |
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Glad to see US universities joining their European colleagues in this fight sciencemag.org/news/2019/02/u…
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Chris D McFarland
@cd_mcfarland
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27. sij 2019. |
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I vote precursor. Similar experiment in a different system is good for proving generalizability, but not that you can implement the experiment.
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Chris D McFarland
@cd_mcfarland
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10. pro 2018. |
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AI just outperformed traditional protein folding algorithms sciencemag.org/news/2018/12/g…
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Chris D McFarland
@cd_mcfarland
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8. stu 2018. |
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@SusanneTilk presenting on the effect of the genome-wide mutation rate on patterns of positive and negative selection in cancer #SACB2018 pic.twitter.com/ILUAyGx7ap
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Chris D McFarland
@cd_mcfarland
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6. stu 2018. |
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Vote! California has day-of voter registration.
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Michael Hallett
@hallettmichael
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13. lis 2018. |
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The first symposium on mathematical and computational oncology (ISMCO), and in a beautiful place. Paper submission is Dec 17. ismco.net
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ᴊᴏʜɴ ᴍᴄᴄᴏʀᴍᴀᴄᴋ
@LAevolving
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24. kol 2018. |
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#Evolution is this:
🐜🦎🐒🙍🏻♀️ (today)
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|_____| ↑
| Time
Not this:
Time →
🐜→🦎→🐒→🙍🏻♀️
#phylomoji
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Dmitri Petrov
@PetrovADmitri
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2. tra 2018. |
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Very proud of this paper by Zoe Rogers, Chris McFarland et al entitled "Mapping the in vivo fitness landscape of lung adenocarcinoma tumor suppression in mice" which just came out in Nature Genetics rdcu.be/Kreq 1/n
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Dmitri Petrov
@PetrovADmitri
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3. tra 2018. |
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And here is a write up by Stanford News: news.stanford.edu/2018/04/03/sta…
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Chris D McFarland
@cd_mcfarland
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9. lip 2017. |
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This was the smartest thing NIH has done in years, and it didn't last a month... sciencemag.org/news/2017/06/u…
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Chris D McFarland
@cd_mcfarland
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26. svi 2017. |
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Excited about this recent FDA approval:
1) Its the first pan-cancer drug,
2) It targets cancer's mutator phenotype technologyreview.com/s/607927/drug-…
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