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Ane Appelt
Physicist, radiation oncology researcher, trialist, data nerd. Unendingly curious; frequent global traveller. Assoc prof at University of Leeds
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Ane Appelt 19h
A fluence of (medical) physicists
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Ane Appelt 24h
Thank you to the organisers for two brilliant days in Baltimore. Very lively discussions of how to improve our understanding of normal tissue dose-effects. Data pooling, statistical methodology, checklists & guidelines, and a whole lot more. Now for the actual work!
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Ane Appelt Feb 26
Replying to @cancerphysicist
Oh well, I guess I’m back in the UK ... (It started hailing the moment I stepped out of the airport 🤷🏻‍♀️)
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Ane Appelt Feb 26
Replying to @DrewMoghanaki
😂😂 (And then I’ll get back down in physics, and quietly continue to rely on a (dose calculation) model to plan every single one of your patients 😉)
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The APHRODITE trial Feb 26
Amazing team effort! 3 days from greenlight approval to first patient in. The quickest patient to be recruited into a radiotherapy trial run at Leeds CTRU
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Ane Appelt Feb 26
Replying to @DrewMoghanaki
But again, since we weren’t narrowly discussing models on Monday / Tuesday, that’s sort of not the important part here
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Ane Appelt Feb 26
Replying to @DrewMoghanaki
I don’t disagree with the first two statements. But I also find that prompting people to formalise their decision making - e.g. in the form of models, even if extremely simple (‘all patients have same probability of response’) - exposes underlying (non-evidence based?) beliefs.
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Ane Appelt Feb 26
Replying to @DrewMoghanaki
Still unclear to me which ‘group belief’ that you’re aware of and I’m not 🤷🏻‍♀️The only shared understanding that I saw was a hope that some(?) of the endpoints we’re interested in in radonc possibly has a dependence on dose, and that’s worth studying. But you may not think so?
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Ane Appelt Feb 25
Replying to @DrewMoghanaki
I can’t conform any preconceived notions that you may have if they were about something other than the meeting which I attended 🤷🏻‍♀️
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dave fuller Feb 25
[PLUG] Can’t wait to hear ’s session at the Pre-Meeting on physicists in clinical trials; we desperately need repped in trial conception and design. Already discussing NTCP-enriched RCTs!
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Ane Appelt Feb 25
Thank you! It was an inspired decision by organisers to put an epidemiologist and a clinical scientist to co-lead the session - I learned a lot. (Even if facilitating the discussion felt a bit like bearding cats ...)
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Ane Appelt Feb 25
Replying to @DrewMoghanaki
I suspect you have a pretty narrow idea of what was discussed. Prediction models in radiation oncology is a pretty broad area, and not just a question of ‘believers’ or ‘non-believers’. And the whole meeting was pretty much people going ‘why aren’t we better’
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Ane Appelt Feb 25
Getting to the wrap-up sessions. promoting the idea of a ‘QUANTEC data science manifesto’ to promote good practice in the community
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Robert C. Miller, MD Feb 25
Beyond QUANTEC - explains the model based selection process for particle therapy patients in the Netherlands.
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Ane Appelt Feb 25
One more proton centre - this time with four treatment gantries, fixed beam line, and hyperthermia therapy (My fifth PT centre visit )
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Ane Appelt Feb 25
Thanks! I did see and read it a month ago, but wanted to comment properly - and then never got back ... I’ve already referenced it in a talk, though! 😀 So as soon as I’m actually back in the office ...
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Ane Appelt Feb 25
Replying to @DrewMoghanaki
Again, not sure I understand. I believe in the concept that we all create more or less complex model representations of the world as part of our decision making process. Not in any particular model.
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Ane Appelt Feb 24
Replying to @DrewMoghanaki
Inasmuch as we all rely on models for assessment and decision making, even if they are so simple that we don’t usually think of them as such - then yes
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Ane Appelt Feb 24
Replying to @DrewMoghanaki
Not sure I understand - believers of what?
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Ane Appelt Feb 24
One of the most enjoyable days I’ve had for a long time - and more to come tomorrow! (And shame on all of you who opted out of the bar and missed the spirited discussions of extensions to the DICOM standard, TRIPOD RT-specific guidelines, and MICCAI modelling challenges ...)
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