If abnormal hemoglobin, is the ferritin displaces from from the rbc’s? Are serum iron levels high? Acute iron toxicity? https://chemrxiv.org/articles/COVID-19_Disease_ORF8_and_Surface_Glycoprotein_Inhibit_Heme_Metabolism_by_Binding_to_Porphyrin/11938173 …
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Ferritin does rise, but also rises with critically ill patients in general. According to that paper, yes, virus cleaves heme, releasing porphyrin which it takes for itself, splitting off iron, a potent inflammatory ion. Acute intracellular iron toxicity?? My question too.
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This is the time that we all should come together (Not physically) to help & protect our country. Hats off to all doctors.
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1/2 Has anyone tried nitric oxide or heliox to promote vasodilation and increase 02 delivery. Also, Covid binds ace2, which results in less ang1-7, and ang1-9, which is protective and its loss leads to acute lung injury and cardiac pathology.
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“Nifedipine can reduce pulmonary vascular resistance and decrease pulmonary artery pressure, and phosphodiesterase 5 inhibitors can increase cyclic guanosine 3’,5’-monophosphate (cGMP) to augment the pulmonary vasodilatory effects of nitric oxide”https://www.acepnow.com/article/tips-for-spotting-and-treating-high-altitude-illness/ …
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Another avenue is use of aceI to restore this balance. Has iv enalaprit been tried for the sickest patients. There is some evidence it may work. https://thorax.bmj.com/content/62/6/527 …. There is also a recombACE2 , apno1 being studied, no results yet..
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