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Kevin Mitchell
Variable prediction accuracy of polygenic scores within an ancestry group - a reminder that polygenic scores can be confounded by all kinds of things... from + colleagues
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Allen Frances 2. velj
Odgovor korisniku/ci @WiringTheBrain @molly_przew
4 serious questions: 1)Which is more complex/difficult to unravel- human brain vs human genome? 2)Will we make major advances understanding how either work before wiping ourselves out via climate, nucs, or AI? 3)Will genetics will ever contribute to clinical psychiatry? 4)How?
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Kevin Mitchell 2. velj
Odgovor korisniku/ci @AllenFrancesMD @molly_przew
All good questions! On (1), I think the complexity of the genome and of the brain are intertwined and understanding that relationship may help ground neuroscience (but I'm probably biased...)
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The unified self is just my MacGuffin. 31. sij
Odgovor korisniku/ci @WiringTheBrain @molly_przew
You could almost change that ‘can’ to a ‘will’.
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Kevin Mitchell 31. sij
Odgovor korisniku/ci @GregCfollows @molly_przew
Well, yeah. Polygenic scores will be more confounded for some kinds of traits than others, with social outcomes like educational attainment or income most susceptible
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Jason H. Moore, PhD 31. sij
Odgovor korisniku/ci @WiringTheBrain @molly_przew
Wait... does this study mean that genetic effects on risk might actually vary depending on the genomic background they find themselves in?
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Kevin Mitchell 31. sij
Odgovor korisniku/ci @moorejh @molly_przew
What? Heresy!
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Michael Hendricks 31. sij
Odgovor korisniku/ci @WiringTheBrain @molly_przew
This should be intuitive to anyone who understands genetics and GxE...takes ignorance or motivated reasoning to take Murray seriously.
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Kevin Mitchell 31. sij
Odgovor korisniku/ci @MHendr1cks @molly_przew
The general idea of GxE interactions is intuitive, but it's not trivial demonstrating these effects as et al have done and many using polygenic scores will be surprised...
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Ian Wardell 2. velj
Odgovor korisniku/ci @WiringTheBrain @molly_przew
What the heck does polygenic mean? Academics need to learn to communicate much more effectively. Otherwise no one will have a clue what they're droning on about and no-one will read their output.
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