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@WiringTheBrain | |||||
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As discussed here: Nature versus nurture: how modern science is rewriting it theconversation.com/nature-versus-… via @ConversationUK
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Dr Adam Rutherford
@AdamRutherford
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29. sij |
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Charles Murray on genetics, as written by four (4) actual geneticists. 🧬 🧬 🧬 🧬
Also Charles Murray on genetics as written by actual Charles Murray 🤨 pic.twitter.com/vZpNRrLQxR
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Kevin Mitchell
@WiringTheBrain
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29. sij |
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It displays a common misunderstanding - that if genetic variants are associated with a trait, then they must be revealing some proximal *biological mechanism*. This is not the case.
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Kevin Mitchell
@WiringTheBrain
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29. sij |
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Of course, for some traits and some variants, there is a direct molecular mechanism underlying the association. (Think of eye colour, for example).
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Kevin Mitchell
@WiringTheBrain
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29. sij |
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But for complex traits (and especially for social outcomes), the effects of genetic differences may also be mediated through environmental or cultural mechanisms
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Kevin Mitchell
@WiringTheBrain
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29. sij |
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For educational attainment, we know this is the case. As described here, for example: The nature of nurture: Effects of parental genotypes science.sciencemag.org/content/359/63… pic.twitter.com/17ii3ufT8D
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Kevin Mitchell
@WiringTheBrain
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29. sij |
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...which showed effects on educational attainment of parental genotypes that were NOT transmitted to the offspring (i.e., mediated by "nurture") pic.twitter.com/tHDiX9BQIr
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Kevin Mitchell
@WiringTheBrain
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29. sij |
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Similarly: Social Competence in Parents Increases Children's Educational Attainment: Replicable Genetically-Mediated Effects of Parenting... ncbi.nlm.nih.gov/pubmed/30661510 pic.twitter.com/kN2rFTQXe5
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Kevin Mitchell
@WiringTheBrain
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29. sij |
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Comparison of adopted and non-adopted individuals reveals gene-environment interplay for education in the UK Biobank biorxiv.org/content/10.110… pic.twitter.com/VkuzDPAYz6
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Kevin Mitchell
@WiringTheBrain
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29. sij |
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So, the idea that polygenic scores for social traits somehow give you a pure look at innate *biological mechanisms* is simply wrong.
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Kevin Mitchell
@WiringTheBrain
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29. sij |
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There will always be a complex interplay of innate predispositions, family environment and societal and cultural factors, often acting in amplifying loops...
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Kevin Mitchell
@WiringTheBrain
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29. sij |
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More than most traits, educational attainment is strongly influenced by the "Matthew effect": For to every one who has will more be given, and he will have abundance; but from him who has not, even what he has will be taken away.
— Matthew 25:29 pic.twitter.com/RJ8CzVx4hQ
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Karin Van Dijk
@sh33p_purple
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30. sij |
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try explaining this to shallow behavioural 'scientists', it's a tour de force. comparable to implementing prediction models with black box processes. the same ignorant mistakes get made over and over again. you'd think we'd gotten rid of John Watson by now.
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