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Christine Stabell Benn Aug 23
With : Most vaccines were introduced without prior testing of their effects on overall health. Once introduced, testing is considered unethical. Health policy changes should be done in RCT-like designs.
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Leif Erik Sander Aug 24
Name a childhood vaccine that you suspect to cause more harm to „overall health“ than it saves lives by preventing the resurgence of deadly diseases. Wouldn’t it be more effective to focus on non-specific benefits of vaccines?
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Christine Stabell Benn
I can unfortunately give you several examples: 1) High-titre measles vaccine was introduced in 1989, it prevented measles but turned out to be associated with 2-fold increased female mortality. It was withdrawn by WHO in 1992
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Leif Erik Sander Aug 26
...You essentially state the same in your DTP paper doi: 10.1093/trstmh/trw073 – So measles vaccine is not the problem. Very important not to sow unwarranted doubt about measles vaccines, which are very safe and extremely effective.
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Christine Stabell Benn Aug 26
Again agree, we have a lot of evidence that the currently used measles vaccine is associated with strong beneficial effects, much stronger than can be explained based on its protective effect against measles.
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Leif Erik Sander Aug 26
2) regarding high titer measles vaccine (HTMV), even Peter Aaby’s paper that you reference concludes that “a change in sequence of vaccinations, rather than HTMV itself, may have caused increased female mortality”.
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Christine Stabell Benn Aug 26
Agree, the underlying problem was that HTMV was given so early that many received DTP vaccine after; the increased mortality was driven by very high mortality in girls who got HTMV-then-DTP. But still a situation where a vaccine was associated with higher overall mortality.
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Leif Erik Sander Aug 26
Thanks, Christine. 1) I fully agree with regards to RTS,S. It is not a good malaria vaccine - as RCTs have shown (!). I agree that it should not be rolled out, based on the inadequate efficacy and safety.
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Lena Brandt Aug 28
The high-titre measles vaccine, was that a non-live/inactivated vaccine? And if so what type of adjuvant was used? I haven’t been able to find information on this
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Christine Stabell Benn Aug 28
It was a live vaccine, and it turned out that the real culprit was non-live vaccines - HTMV was given so early that many children got non-live DTP (or IPV) afterwards - mortality was only increased in these children.
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