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ShorterLab
We elucidate how to counter deleterious protein misfolding in ALS, FTD, PD, AD, and related disorders
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Penn May 18
Cloudy days can’t hide impressively green views.
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ALS Research Forum May 18
A new study suggests that TDP-43 and FUS build up in the cytoplasm in neurons in by passive diffusion, stoking the debate about how to reduce this potentially key source of neurotoxicity in the disease
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Penn May 17
President Gutmann's words from Commencement have been echoing in our ears. "We cherish: Liberty not Chains, Opportunity without Limit, Love without Condition, and Learning without End."
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Alzforum May 18
TDP-43 and FUS escape the nucleus by passive diffusion, not active transport. Will this affect therapeutic strategies for and ?
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ShorterLab May 18
Astrocytes expressing ALS‐linked mutant FUS induce motor neuron death through release of tumor necrosis factor‐alpha:
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ShorterLab May 17
Ataxin-2 Is Droppin’ Some Knowledge:
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ShorterLab May 17
RNP-Granule Assembly via Ataxin-2 Disordered Domains Is Required for Long-Term Memory and Neurodegeneration:
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ShorterLab May 17
Conformational Activation of Argonaute by Distinct yet Coordinated Actions of the Hsp70 and Hsp90 Chaperone Systems:
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ShorterLab May 17
The Eukaryotic Proteome Is Shaped by E3 Ubiquitin Ligases Targeting C-Terminal Degrons:
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D. Allan Drummond May 17
An incredible clinic on how RNA sequence and secondary structure dictate formation of specific phase-separated assemblies from Amy Gladfelter. In vitro and in vivo work — with preprint!
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Steven Boeynaems May 17
Reentrant phase transitions shown by Deniz. Excess RNA dissolves R-rich droplets from the inside out.
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Steven Boeynaems May 17
teaching us all a lesson in NMR. Exciting new data showing dispersed interactions in QGSY of FUS, contradicting specifc single zipper as driver of phase sep. Really important advance to the field. TDP phase sep dissection with
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Steven Boeynaems May 17
Nott shows that different Ddx LCD droplets have differential material properties and DNA duplex melting activity. Interesting look into the complex determinants underlying these behaviors.
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ShorterLab May 17
Better Together: A Hybrid Amyloid Signals Necroptosis:
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Mike Harms May 16
Great papers by and Tawfik/Noel labs tracing evolution of enzymes from non-enzymes. , . Privileged to write about their amazing science in a News & Views. .
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ShorterLab May 16
Spatiotemporal regulation of liquid-like condensates in epigenetic inheritance:
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Raff Lab May 16
Interesting data by Geraldine Seydoux on the phases of P granules & thought-provoking conclusion that RNA granules overall could require active processes to remain liquid at the core
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ALS Research Forum May 16
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David W. Sanders! May 15
Right back at you from Princeton!
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Brady Lab May 15
A double dose of luck here & tonight while 🤓☘️🌈
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