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JExpMed
The Journal of Experimental Medicine publishes immunology, cancer, stem cells, microbial pathogenesis, vascular biology, neurobiology. Est. 1896 -
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JExpMed Jul 19
Sensing of apoptotic cells through Axl causes lung basal cell proliferation in inflammatory diseases
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Rockefeller U. Press Jul 19
H&E staining of mouse small intestine. Hyung Sin et al.
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JExpMed Jul 19
Rana et al. demonstrate that white adipose tissue-resident multipotent stromal cells support IL-33– and LFA-1/ICAM-1–mediated proliferation and type-2 cytokine expression by ILC2
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JExpMed Jul 19
The ubiquitin-editing enzyme A20 controls NK cell homeostasis through regulation of mTOR activity and TNF
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Marrah Lachowicz-Scroggins Jul 19
If you are interested in pulmonary neuroendocrine cells (PNECs) here is a study in that generated PNECs through directed differentiation of hESCs to understand correlation between cancer genotypes and lineage phenotypes.
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JExpMed Jul 18
Inherited IFNAR1 deficiency in otherwise healthy patients with adverse reaction to measles and yellow fever live vaccines
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bart lambrecht Jul 17
This is a collab between our lab and Sophie Janssen lab. A20 (Tnfaip3) keeps on surprising. Function is highly dependent on cell type, sometimes cytoprotective, sometimes pro-apoptotic. has published lots on this.
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JExpMed Jul 18
ILC3s integrate glycolysis and mitochondrial production of reactive oxygen species to fulfill activation demands
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Rockefeller U. Press Jul 18
. highlighted an article in (Beura et al. ), that used classical parabiosis of mice—a technique for establishing surgical union of two circulatory systems—to define CD4+ T cell tissue residency:
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JExpMed Jul 18
Itch is a catalytic ubiquitin ligase that prevents autoimmunity. Moser et al. show that Itch negatively regulates B cell proliferation and metabolic fitness to limit antigen-driven B cell responses and antibody production after immunization
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JExpMed Jul 17
Natural killer (NK) cells switch from granzyme B to death receptor–mediated cytotoxicity during serial killing
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JExpMed Jul 17
Axl expression by basal cells within the lung epithelium causes cell cycle reentry and symmetric division. Sustained Axl stimulation in the presence of apoptotic cells is implicated in epithelial hyperplasia in inflammatory lung disease
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JExpMed Jul 17
A stromal cell niche sustains ILC2-mediated type-2 conditioning in adipose tissue
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JExpMed Jul 17
Vetters et al. identify the ubiquitin-modifying enzyme A20 as a critical regulator of mTOR. Loss of A20 unleashes mTOR activity and induces NK cell death, underscoring the need for a tightly controlled mTOR pathway for NK cell homeostasis
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JExpMed Jul 16
Thioesterase PPT1 balances viral resistance and efficient T cell crosspriming in dendritic cells
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CFCD Jul 16
Identification of the Thioesterase PPT1 as important novel player balancing viral resistance and efficient T cell crosspriming by type 1 in
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JExpMed Jul 16
Hernandez et al. describe two unrelated patients with inherited IFNAR1 deficiency who suffered from life-threatening infections following measles or yellow fever virus vaccination and were otherwise healthy
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Rockefeller U. Press Jul 16
According to a study () tissue-resident memory T cells are key tumor fighters, with a unique ability to seek out and kill tumor cells without suffering from the phenomenon of T cell "exhaustion." Read more :
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JExpMed Jul 16
ILC3s are innate immune cells in the intestine that contribute to mucosal barrier integrity and support antimicrobial responses. Di Luccia et al. show that an mTORC1-HIF1α–mediated metabolic program sustains ILC3 numbers and activation
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JExpMed Jul 15
Identification of monocyte-like precursors of granulocytes in cancer as a mechanism for accumulation of PMN-MDSCs
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