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International Brain Laboratory
After >2 years of effort by our team in 7 labs, we present to you: 3 million choices from 101 mice in a standardized decision-making task. 🐭 "A standardized and reproducible method to measure decision-making in mice" Story time! 🧵👇 1/10
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International Brain Laboratory 18. sij
Odgovor korisniku/ci @IntlBrainLab
Mice 🐭 are excellent decision-makers, and can learn to perform complicated tasks. So far, such behavior often relied on custom-built setups, and required the 'artist's hands' of experienced mouse whisperers. 2/10
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International Brain Laboratory 18. sij
Odgovor korisniku/ci @IntlBrainLab
However, to study the neural basis of decision-making, we need reliable paradigms for mouse behavior! Our team established standardized methods to ensure the of mouse behavior across different labs. 3/10
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International Brain Laboratory 18. sij
Odgovor korisniku/ci @IntlBrainLab
After teaching 101 mice the same behavioral task, we asked if their behavior was really reproducible across labs. A trained classifier was not able to tell which lab each mouse came from. We've never been so happy to see a classifier fail! 4/10
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International Brain Laboratory 18. sij
Odgovor korisniku/ci @IntlBrainLab
We also trained mice on a variant of the task, where they integrate priors into their decision strategy. Across different labs, mice use this information in a similar way. 5/10
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International Brain Laboratory 18. sij
Odgovor korisniku/ci @IntlBrainLab
In the process, we developed a ton of resources that we'd love the community to use. In the Appendix you'll find guides to surgery and mouse training 6/10
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International Brain Laboratory 18. sij
Odgovor korisniku/ci @SanworksLLC
With , we've designed easy-to-build rigs that you can put together from off-the-shelf, open-source parts and some 3D printed components. At , we built it in 1 day! Parts list and instructions: 7/10
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International Brain Laboratory 18. sij
Odgovor korisniku/ci @IntlBrainLab
We’ve also figured out how to work together in large, distributed groups. Our team is in 22 labs, across 15 research institutes - with 9 hours time difference 🕑 8/10
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International Brain Laboratory 18. sij
Odgovor korisniku/ci @DataJointNeuro
Of course, the code and data are all open. Huge thanks to for the beautiful interactive visualizations. 9/10
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International Brain Laboratory 18. sij
Odgovor korisniku/ci @IntlBrainLab
We're now using these methods and infrastructure to record brain activity while mice perform this decision-making task. Watch this space for spikes! 🧠⚡️ 10/10
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International Brain Laboratory 18. sij
Odgovor korisniku/ci @wellcometrust @SCglobalbrain
And of course, none of this would have been possible without the support of and .
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