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Garnett Lab
team investigating how abnormalities in the DNA of cells contribute to cancer and impact on patient responses to therapy.
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Garnett Lab retweeted
Human Technopole 18h
Today from HT Centre for Computational Biology held a virtual seminar about prioritising cancer therapeutic targets via CRISPR-Cas9 screens and multi-omics data integration
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Garnett Lab retweeted
Jeremy Farrar 18h
Wellcome Trust building to become respite centre for local NHS staff
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Inigo Martincorena Apr 2
Replying to @imartincorena
[14 days later] With caution, given the uncertainty in diagnosed cases, the epidemic appears to have grown at ~17% per day in the UK (similar to Italy 14 days before) the week before the lockdown, despite the calls for social distancing.
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Inigo Martincorena Mar 19
As far as I can see, the UK is running out of time to avoid reaching a situation like Italy's or Spain's. Some data and analyses below. Apologies for any mistakes and please challenge or correct any claims. Data source: [1/11]
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Garnett Lab Apr 2
Many congratulations Andrew!
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Garnett Lab retweeted
preLights Mar 20
Genome-wide CRISPR screens and drug screens come together to reveal cancer drug mechanism-of-action. first by on from & co.
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Jonathan Weissman's Lab Mar 30
Perturb-seq is a powerful tool for understanding genes and genetic networks at the single-cell level. We developed a method for large-scale Perturb-seq screens with flexible guide designs and targeted sequencing. Check out our work in :
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Hans Clevers Mar 30
In case you have too much time on your hands in these strange weeks...
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Panos Zalmas Mar 27
Join me at the hugely supportive environment of and Only a few days left to apply!
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Jesse Boehm Mar 26
Mystery: why do ~230/1000 historical cancer cell lines not transcriptionally match primary tumors? Are they great models of resistant/metastatic tumors instead? Or artifacts of culture? Matching models with tumors is key. Read Allie, James, Aviad's Celligner paper!
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Inigo Martincorena Mar 23
Replying to @imartincorena
[Monday update] The UK epidemic is doubling in size every ~3 days, the same rate as Italy at the same stage of their epidemic, lagging just 14-15 days behind. The UK epidemic is now likely ~4-5 times larger than it was last Monday. ~4-5 times larger than it ever needed to be.
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Cancer Dependency Map Sanger Mar 23
This is important work to track and prevent further transmission of . It leverages world-class capabilities for DNA sequencing and analysis built up over decades. Thanks to the dedicated team and across the UK making this possible.
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Inigo Martincorena Mar 22
Coverage by The Telegraph of the analyses I have been posting in the last few days. The UK's epidemic is lagging 14-15 days behind Italy's and doubling at the same rate. We should have gone into lockdown on Monday *just* to be hit as badly as Italy is now.
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Postdoc Matters Mar 20
There's an urgent call to depts for surplus supplies to support workers - if you know of any surplus in your dept please get in touch with us. View a list of what is needed here:
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Georgina Sava Mar 20
Really pleased to have joined the community! Here is my first preLight...
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Elizabeth McDaniel Mar 20
There’s a lot of interest right now for learning bioinformatics skills while lab research is suspended and everybody is working from home. I wanted to share *free* resources for learning coding basics and field-specific materials. Thread (1/n)
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Sanger Institute Mar 20
Due to the rapidly changing COVID-19 pandemic, we and our neighbours at will be closing all but essential operations from Friday 20 March.
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NEJM Mar 18
Neurofibromatosis involves activation of the RAS pathway. Inhibition of MEK, a component of the pathway, with selumetinib was performed in 50 children with inoperable disease. A total of 70% had a response, which was maintained in the majority for more than a year.
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Hayley Sharpe Mar 19
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🏴󠁧󠁢󠁷󠁬󠁳󠁿🇬🇧James Wells Mar 18
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