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Bart Deplancke
Professor@EPFL, opinions my own cell genomics stem cells (MSCs) Genetics medicine
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Bart Deplancke Jun 28
Recently Evolved Enhancers Emerge w/ High Interindividual Variability and Less Frequently Associate With Disease "enhancers containing trait-associated variants are preferentially conserved. In contrast, most human-specific enhancers are highly variable"
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Bart Deplancke Jun 22
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Bart Deplancke Jun 22
Interesting new paper by lab "length of G1 & # of cell divisions is regulated during the differentiation process by competition mechanism b/w cyclin D1 & PPARG-induced expression of p21" -
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Bart Deplancke retweeted
Molecular Cell Jun 16
Online Now: Intrinsically Disordered Regions Direct Transcription Factor In Vivo Binding Specificity
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Bart Deplancke Jun 10
Replying to @Duboule @ETH_en @EPFL
8 more to go 😅
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Bart Deplancke Jun 10
For all those interested in pursuing an industry career or with start-up ambitions in the life sciences domain, this course is highly recommended, led by industry leaders in the field.
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Bart Deplancke Jun 9
Knowing Helena, this would be a great lab to go to!
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Bart Deplancke Jun 5
Very cool, new method by the Quake Lab "Smart-seq Total" pioneered by our former lab member 👏 --> "we show that cell types can be distinguished based on the abundance of non-coding transcripts alone"
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Bart Deplancke retweeted
EPFL Life Sciences Jun 2
FloChiP, a new tool optimizing gene-regulation studies New tech from
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Bart Deplancke Jun 2
Replying to @BartDeplancke
We demonstrate FloChIP’s HT capacity by performing ChIP-seq on MEF2A in 32 distinct lymphoblastoid cell lines, using genetic variation to provide novel insights into the drivers of MEF2A collaborative DNA binding (with RUNX3 being a key factor) & into its role in B-cell function
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Bart Deplancke Jun 2
V. pleased w/ outstanding work by et al. engineering a new microfluidic platform FloChIP to enable highly parallelized (either antibodies or samples) & automated individual or sequential ChIP-seq of histone marks & TFs
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Bart Deplancke retweeted
Sophie G Martin May 28
Please RT! The Martin lab has two open positions to study the roles of in transport and Cdc42 in cell fusion. We use advanced live-imaging, CLEM and the really awesome fission yeast model! /3
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Bart Deplancke May 26
Thanks Stein, much appreciated. And yes, great to streamline the SCope-ASAP crosstalk! Can we hire you as our spokesperson BTW? ;))
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Bart Deplancke May 26
Great job by et al releasing ASAP2020: , our (sc)RNA-seq analysis tool w/ remodeled user interface & implementation of the .loom file format , able to handle millions of cells. Tx to for funding!
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Bart Deplancke May 24
Great collaboration with the lab using our new “no cell left behind” DisCo scRNA-seq platform () to reveal “Multimodal and multisensory coding in the Drosophila larval peripheral gustatory center” ()
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Bart Deplancke May 24
Everyone interested in the mysteries underlying variation in differentiation efficiencies needs to read this paper, since the observed variation is remarkable and the generated data massive, so the big question is "why?", and this is exactly what this study tries to detangle.
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Bart Deplancke May 22
Big thanks of course also to our collaborators Esther Amstad Wouter Saelens Manfred Claassen Lab & EPFL core facilities for their support!
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Bart Deplancke May 22
Replying to @BuesJohannes
Great work by & @gosdpodin_hatz et al 🙏! Here’s our deterministic co-encapsulation in action!
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Bart Deplancke May 22
Our new scRNA-seq “no cell left behind” DisCo tech, longtime coming 😅! Application on 31 individual intestinal organoids revealed new gobloid subtype & spheroids comprised of a second regenerative fetal-like Ly6a+ stem cell population
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Bart Deplancke May 21
Excellent work yet again by lab!
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