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@AnnalisaSheehan | |||||
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Our paper in @DiabetologiaJnl is out today! We report associations between childhood Type 1 Diabetes (T1D) and a wide range of environmental factors across England. @DrSusanHodgson @daniela_fecht @CentreEnvHealth @imperialcollege rdcu.be/b0KIE pic.twitter.com/o7bgxujOt4
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Annalisa Sheehan
@AnnalisaSheehan
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27. sij |
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We used data for ~14,000 childhood T1D cases and assessed relationships at the local authority level using a novel approach- Environment Wide Association Study (EnWAS). We used Bayesian methods to include the spatial component of the data in the analysis.
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Annalisa Sheehan
@AnnalisaSheehan
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27. sij |
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We found a strong spatial structure (78%) in disease risk across England. Higher relative risks were found in coastal and more rural areas. pic.twitter.com/o1ZJj11jVo
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Annalisa Sheehan
@AnnalisaSheehan
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27. sij |
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15 out of 53 demographic and environmental risk factors were significantly associated with T1D, including: air pollutants (PM10, NO2, NOx, CO), lead in soil, radon, outdoor night at light, IMD living environment domain, overcrowding, population density and ethnicity. pic.twitter.com/zO5a27Douy
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Annalisa Sheehan
@AnnalisaSheehan
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27. sij |
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These results pave the way for further investigation as to why coastal and rural areas showed higher rates of T1D than urban - what are the mechanisms driving these trends?
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