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Adam Marblestone 17. srp
Sewing-machine insertion of flexible electrodes via small holes. Good progress on channel count + insertion, building on 's work. Also nice chip+packaging. Hard stuff. Much depends on gliosis, but Chong Xie's results promising. Laser would indeed be preferable to drill. 1/4
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Christian Wentz 17. srp
Odgovor korisniku/ci @AdamMarblestone @m8ta
🤦🏻‍♂️ if you’re putting electronics inside the skull, flexible electrodes will lose long term to optical readout. Nearly all hard problems unsolved here, animal model doesn’t translate (vasculature, insertion depth), hermeticity, reg burden unproven. Feel like we’ve been here...
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Andrew Hires 17. srp
Optical readout has problems too. Need to express sensor genes stably and safely. Can't see more than 200um deep without 2-photon, which is not getting minaturized to a wearable probably ever. Even with 2p, can't get over 700um deep. Implantable lenses cause huge damage...
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Christian Wentz 14. kol
Odgovor korisniku/ci @AndrewHires @AdamMarblestone @m8ta
2-photon and sensor genes are not the only options here...
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Andrew Hires 14. kol
...unless you want cellular resolution instead of measuring blood flow/oxygenation...
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Andrew Hires 14. kol
Willing to consider other plausible mechanisms with citation. (e.g. photoacoustic imaging of activity dependent contrast agent with resolution enhanced via adaptive optics corrected by ultrasound-induced cavitation guidestars...). A TED talk is not a citation. What u got?
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Adam Marblestone 14. kol
Odgovor korisniku/ci @AndrewHires @ChristianWentz @m8ta
Agreed. I wish we could continue this in detail...! There are a lot of smart people thinking outside the box at Kernel and elsewhere though...
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