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Anand Ranganathan Mar 19
As Italy struggles, and as mentions Chloroquine and HydroxyChloroquine as treatments for SARS-CoV, I think of an Italian who proposed this first. 17 years ago. Grazie, Dr Andrea Savarino (). The world owes you a debt.
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Anand Ranganathan Mar 20
Replying to @ARanganathan72
In the 2016-17 Flu season an estimated 24,981 Italians aged 65 and above died from Flu (143 per 100,000 population). 4,200 deaths per month. Not because of but Seasonal Flu. Did you know of this back then?
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Anand Ranganathan Mar 21
Replying to @ARanganathan72
In a (non-peer-reviewed) paper published today, scientists from Hong Kong report on stability of the corona virus that causes CoVID-19. Strikingly, a significant level of infectious virus could be detected on the outer layer of a mask even after a week.
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Anand Ranganathan Mar 21
Replying to @alexlachmann
Interesting study published (non-peer-reviewed) today by Prof , that estimates CoVID-19 cases in China could be as high as 702,000 and not 80,000 as reported.
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Anand Ranganathan Mar 22
Replying to @ARanganathan72
Two (non-peer-reviewed) studies published today with non-Human primates infected with SARS-CoV-2 disclose that the virus is intermediate in its severity between MERS and SARS-CoV-1, and that reinfection DOES NOT occur once the monkey is cured of CoVID-19.
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Anand Ranganathan Mar 22
Replying to @10DowningStreet
Live : The UK is planning to totally isolate its 1.5 million vulnerable population for 3 months. This is what one of its top scientific advisors had said a week ago: Ideally I'd like to isolate all the vulnerable and expose everyone else to a "nice big epidemic".
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Anand Ranganathan Mar 23
Replying to @ARanganathan72
A great resource of all the CoVID-19 tests currently available or awaiting approval. The simple Antibody test - that detects antibodies against SARS-CoV2 in blood using a SARS-CoV2 protein (probably the Spike protein) as bait - would greatly help India.
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Anand Ranganathan Mar 23
Replying to @drharshvardhan
Why is it VITAL for India to procure Antibody test? 1. Will increase testing speed, allowing more of the infected to be isolated. 2. Will give us, and this is CRUCIAL, an estimate of the population already cured of CoVID-19 (i.e. has antibodies but no disease).
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Anand Ranganathan Mar 23
Replying to @ARanganathan72
10% of Human genome is made up of viral DNA. It is vital for our survival and, among other things, fetal development. Humans already have parts of SARS-CoV-2 (CoVID19) Spike protein [prefect N-terminal match with Human Ephrin Receptor. Analysis predicts it to be a signal.]
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Anand Ranganathan Mar 23
Replying to @TimesNow @RShivshankar
India must procure CoVID antibody test IMMEDIATELY. It will not only greatly aid the social distancing effort, but also give VITAL epidemiological data necessary to quell panic. This and other points, on with .
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Anand Ranganathan
Excellent (non-peer-reviewed) study published today by Indian scientists reveals a unique mutation in the Indian SARS-CoVID-2 strain, and also that the potently anti-viral human microRNA (miRNA) hsa-miR-27b has a target ONLY in the Indian strain.
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Anand Ranganathan Mar 24
Replying to @ARanganathan72
March 24 status: Italy. Tested: 206,886 Confirmed cases: 69,176 Deaths: 6820 Death rate: 9.8% Germany. Tested: 167,000 Confirmed cases: 32,781 Deaths: 156 Death rate: 0.4%
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Anand Ranganathan Mar 25
Replying to @drharshvardhan
Dear , FYI Berlin-based company Pharmact () has now begun shipping its CoVID-19 Antibody detection test, based on 3 SARS-CoV-2 proteins. 100% specificity; upto 92% IgM & 98.6% IgG sensitivity. India NEEDS this kit at once. Millions of them.
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Anand Ranganathan Mar 25
Replying to @drharshvardhan
Brilliant idea, dada. , please have a look. In fact, if I may - why not construct an MIP (Mycobacterium Indicus Prani) strain expressing a SARS-CoV-2 protein, e.g. N or the S1 protein? Wouldn't that vaccine elicit stronger immune response?
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Anand Ranganathan Mar 25
This is an ESSENTIAL read, by , on how day by day, decision by decision, the and its Chief sold us out. Samir tallies the reaction of WHO to SARS-CoV-1 back in 2003, and to SARS-CoV-2 now. The difference is stark, and SCARY.
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Anand Ranganathan Mar 26
Replying to @neelbs
An NPR study published by identifies CoA of the freely available anti-epilepsy drug Epilex binding to SARS-CoV2 RDRP. Another study just identified this drug as binding to Human HDAC2 that is used by SARS-CoV2. Two birds with one stone. BRILLIANT.
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Anand Ranganathan Mar 28
Replying to @ARanganathan72
Interesting paper (non-peer-reviewed) just out from Oxford suggests that by March 19, 68% of the UK population was ALREADY infected with CoVID-19 (R0=2.25). This translates to the death rate because of CoVID-19 in the UK to be 0.16%, SAME as seasonal flu.
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Anand Ranganathan Mar 28
Replying to @ARanganathan72
A non-peer-reviewed paper published today proposes Theaflavins, found in large quantities in Black Tea, as inhibitors of SARS-Cov-2 (). A 2005 peer-reviewed study found Theaflavins potently inhibiting SARS-CoV-1 protease ().
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Anand Ranganathan Mar 28
Replying to @ARanganathan72
Unrelated, a team of French & Indian scientists report today (non-peer-reviewed) that Theaflavins, found in very high quantities in CTC Assam Tea not only potently block Hepatitis C Virus entry into human cells, they also prevent cell-to-cell virus spread.
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Anand Ranganathan Mar 29
Replying to @ARanganathan72
Had said this two weeks ago, and I repeat: the only way to quell panic is through true estimation of CoVID death rate (CFR); and that is why it is VITAL to test millions with the antibody test kit [RT-PCR can't tell you if you had CoVID but recovered].
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Anand Ranganathan Mar 29
Replying to @TimesNow
The prolonging or curtailing of the lockdown is inextricably linked to the antibody test. ONLY the antibody test can give us a true estimate of the extent of spread, or danger, the CoVID epidemic poses for India. My views on .
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Anand Ranganathan Mar 29
Replying to @dasgobardhan
Preliminary evidence but I congratulate dada, India's top immunologist. He told me the exact same TWO weeks ago. Paper just out today (non-peer-reviewed) establishes a correlation between CoVID19 cases/deaths and BCG vaccination. MUST-READ.
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Anand Ranganathan Mar 30
Replying to @dasgobardhan
Australia has fast-tracked BCG vaccination trial for CoVID-19. Germany is going to try a boosted BCG variant that has its urease C gene replaced with the listeriolysin gene from Listeria monocytogenes. cc
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Anand Ranganathan Mar 30
Replying to @TimesNow @RShivshankar
What do our numbers mean, and what should be our plan, as we move in to the next crucial week of the lockdown. My views on with .
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Anand Ranganathan Mar 31
Replying to @ARanganathan72
BRILLIANT. Germany to use the Antibody test to screen 100,000 people at a time and then issue all-clear certificates to them so they can re-enter the workforce. Way to go. WE NEED TO DO THIS.
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Anand Ranganathan Mar 31
Replying to @ARanganathan72
Detailed SNP and dN/dS study of 95 SARS-CoV-2 genomes by Indian scientists published today (non-peer-reviewed) points to a rapidly evolving viral replicative machinery so as to evade host response. [2 of the 95 genomes were from Indian CoVID-19 patients.]
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Anand Ranganathan Mar 31
Replying to @ARanganathan72
A study (non-peer-reviewed) just published, of 133 patients with moderate, severe, and critical cases of CoVID-19 finds the Antibody test superior to RT-PCR detection of SARS-CoV-2.
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Anand Ranganathan Apr 1
Replying to @ARanganathan72
In silico analysis published today (non-peer-reviewed) throws light on the increased infectivity of SARS-CoV-2 compared to SARS-CoV-1. In binding to human ACE2 to gain entry, SARS-CoV-2 S protein out-competes even the natural ACE2 binder ATR1 by 64% (BA).
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Anand Ranganathan Apr 1
Replying to @ARanganathan72
Fascinating. Always wondered why SARS-CoV-2 infects lungs more than intestines. Turns out intestines have a molecule α-Defensin-5 (HD5) that binds ACE2 receptor and stops the virus from binding to it first, says a study published today (non-peer-reviewed).
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Anand Ranganathan Apr 1
Replying to @ARanganathan72
Like humans, monkeys also produce Defensins, small peptide molecules that are anti-microbial in nature. Here, a 2009 study reports how a monkey Defensin (RTD-1) prevented death in SARS-infected mice.
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Anand Ranganathan Apr 2
Replying to @ARanganathan72
21% of all Indian CoVID-19 cases attended the Tablighi Jamaat congregation at Delhi. 434 out of 2034 cases. 32% of all Indian CoVID-19 deaths are linked to the Tablighi Jamaat. 19 out of 58. That's a super-spreader if ever there was one.
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Anand Ranganathan Apr 2
Replying to @ARanganathan72
“Courage isn’t a matter of not being frightened. It’s being afraid, but doing what you have to do anyway.” How to Protect the Protectors. A MUST-READ guide for doctors fighting CoVID-19, by Dr Zarir Udwadia, one of India's top chest physicians.
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Anand Ranganathan Apr 2
Replying to @ARanganathan72
Stunning capture at 2000 frames per second by an MIT scientist shows that a human sneeze can travel upto 26 feet. Each sneeze contains 40,000 droplets and millions of virus particles. This work has direct implications for WHO social distancing guideline.
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Anand Ranganathan Apr 3
Replying to @ARanganathan72
Research published today (non-peer-reviewed) by Swedish scientists raises questions regarding the role of ACE2 - human receptor used by SARS-CoV-2 to gain entry - for infection of lungs. The scientists checked for the presence of ACE2 in all human tissues.
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Anand Ranganathan Apr 6
Replying to @ARanganathan72
Anti-SARS-CoV2 antibodies detected in cats. Cats can be infected with CoVID-19 according to a just published (non-peer-reviewed) study.
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Anand Ranganathan Apr 6
Replying to @ARanganathan72
French scientists report today (non-peer-reviewed) of hitting a library of FDA-approved drugs against SARS-CoV-2. AZ and CLQ analogues dominate but another promising drug (EC50 of 5) crops up - Alprostadil, a vasodilator used against erectile dysfunction.
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Anand Ranganathan Apr 8
Replying to @ARanganathan72
India. Tests done: 1,21,271 Positive cases: 5194 (4.2%) Deaths: 149 Death Rate: 2.8 % USA. Tests done: 1,920,000 Positive cases: 400,549 (20.8%) Deaths: 12,857 Death Rate: 3.2% Italy. Tests done: 721,732 Positive cases: 135,586 (18.7%) Deaths: 17,127 Death Rate: 12.6%
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Anand Ranganathan Apr 9
Replying to @dasgobardhan
As one who has been working on Δ ACE2 Mesenchymal Stem Cells (MSCs) for a decade, dada this requires your immediate input. Paper published today finds MSC injection helped cure severe CoVID cases. You have MSCs in the lab. Test this ASAP!
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Anand Ranganathan Apr 9
Replying to @ARanganathan72
Japanese scientists report today (non-peer-reviewed) the testing of 9 anti-HIV drugs against SARS-CoV-2 (in cell cultures). They find the widely available drug Nelfinavir works best, even better than the currently prescribed anti-CoVID Lopinavir.
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Anand Ranganathan Apr 9
Replying to @PMOIndia @TimesNow
Don't kill private labs, dear judges. 1 million RT-PCR tests cost 450 cr; 1 million Antibody tests cost 30 cr [We need more of the latter.] Surely can foot this bill, or if it can't, we will through a cess. My views on .
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Anand Ranganathan Apr 10
Replying to @ARanganathan72
Research just published finds well-known anti-HCV drug β-D-N4-hydroxycytidine (NHC) & its orally bioavailable version kills SARS-CoV-2 and other corona viruses (like Human NL63; 2006 AAC study [not cited], pic 2) in vitro by causing a Mutation Catastrophe.
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