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Stefan Marciniakđź’™ Jun 6
Hydroxychloroquine It doesn’t work in post-exposure prophylaxis (v early) It doesn’t work in hospitalised patients (late) But, but, but (cry its proponents) you have to take it with zinc, under a full moon, clicking your heals 3 times
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CAN’T FRACK THIS UP Jun 6
Replying to @Prof_Marciniak
âś… Such doses on severe patients in RECOVERY TRIAL are staggering: 2000mg / 24h then 400mg / 24h then 800mg / 24hours for 9 additional days âś… Or: 9600 mg of treatment = 1.6 times more than recommended by Pr Raoult âś… Control group mortality 23.5% - > very ill patients
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Stefan Marciniakđź’™ Jun 6
Replying to @AUSBATTERYGRAD1
Thanks. The NEJM paper at top of thread is post-exposure prophylaxis (ie v early & v mild), also negative. I’d encourage you to study the Raoult HCQ papers. The errors are remarkable. Useful only for teaching.
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Stefan Marciniakđź’™ Jun 6
This provides a fascinating & thorough summary of the original Raoult paper. I strongly suggest you read it (by ) Accepted in 1 day Ethics timing is odd Omitted data cf original protocol Patients missing (see why!) Inconsistent analyses
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CAN’T FRACK THIS UP Jun 6
How do you explain the high to doses of HCQ in the now abandoned Recovery trial? How could the hospitals of the world got the pharmacology so wrong??
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Stefan Marciniakđź’™ Jun 6
The dosing was carefully calculated based on the then known in vitro IC50 of HCQ for SAR-CoV-2. Owing to the long half-life of HCQ similar high blood levels are reached in longterm treatment of, say, rheumatoid arthritis. Read about loading doses for meds with long half-lives.
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CAN’T FRACK THIS UP Jun 6
But had totally different calculations???
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Stefan Marciniakđź’™ Jun 6
Don’t know that person so can’t say. Some people erroneously look at dosing for chronic conditions and assume this is right for every situation. In covid19, if HCQ was ever going to work we needed to reach the IC50 immediately.
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Hannah | Hehua Huang
Based on the PK modeling, the IC50 of HCQ can be reached under the daily 400mg dosage regimen, with 800mg as the loading dose.
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